Tyler Stehling threw for 407 yards and five touchdowns, both career highs, and Rice raced to a 65-44 victory over Prairie View on Saturday.
Austin Walter had two touchdown receptions and ran for a third score. Stehling threw scores to five different receivers and the Owls (1-6) amassed 634 yards against the FCS Panthers (4-3). Wide receiver James Mayden also threw a 27-yard TD pass.
Rice led 45-14 at the half, the most in a half since scoring 56 against North Texas in 2008.
Samuel Stewart ran for 116 yards and a TD for Rice and Terri Alaka had a career high 143 yards on six receptions.
On back-to-back possessions in the first half, Kylen Granson had his first career score on a 50-yard pass from Stehling and quarterback J.T. Granato had a 4-yard TD on his first career carry.
Darius Floyd had six catches and 139 yards for Prairie View.