Brian Hill had career highs with 289 yards rushing and three touchdowns, quarterback Josh Allen ran for two more scores and Logan Wilson intercepted a pass in the final minute to help Wyoming hold off Nevada for a 42-34 win on Saturday night.
The Cowboys (5-2, 3-0 Mountain West) had a season-high 403 yards rushing and improved to 3-0 in conference play for the first time since 1998, their final season in the Western Athletic Conference.
Hill had runs of 20 and 39 yards during a nine-play, 80-yard drive that was capped by Allen's 7-yard TD run that made it 42-27 with 2:52 left.
On their ensuing drive, the Wolfpack (3-5, 1-3) went 75 yards in 2 minutes, 12 seconds and James Butler recovered his own fumble in the end zone to pull within 42-34.
Nevada recovered an onside kick, but on its next play from scrimmage Wilson's interception sealed it.