Quentin Flowers and Marlon Mack ran for two touchdowns apiece and Mack became South Florida's career rushing leader as the Bulls scored the final 28 points to beat Cincinnati 45-20 on Saturday night.
Mack finished 118 yards on 20 carries, including a 49-yard touchdown run in the fourth quarter that moved him past Andre Hall into first on South Florida's career rushing list. Mack, a junior, has 2,755 yards rushing in 28 career games.
Flowers completed 16 of 26 passes for 196 yards and added 74 yards rushing.
Mack's first touchdown, a 4-yard run, gave USF (4-1, 1-0 American Athletic Conference) a 24-20 lead with 1:40 left in the first half.
Flowers scored on a 19-yard run with 4:29 to play in the third quarter and, fewer than 3 minutes later, Johnny Ward returned an interception 11 yards for a touchdown to make it 38-20.
Bearcats' freshman Ross Trail threw for one touchdown and ran for another but threw three interceptions before being replaced by Gunner Kiel after Ward's pick-six. Tion Greene had 98 yards rushing and a touchdown on 12 carries for Cincinnati (3-2, 0-1).
South Florida - The Bulls came into the game ranked 24th in the FBS with eight takeaways. They had four more against the Bearcats: three interceptions and a fumble recovery.
Cincinnati - Kiel, who threw 40 combined touchdown passes in 2014 and 2015, completed his first three passes before finishing 3-of-11 passing for 47 yards. Sophomore Hayden Moore started the first three games of the season, throwing for 785 yards with seven TDs and three interceptions, before injuring his ankle in a 40-16 loss to Houston on Sept. 15.
South Florida - The Bulls host East Carolina in its second conference game October 8 at noon. USF edged East Carolina 22-17 in 2015.
Cincinnati - The Bearcats travel to Connecticut on October 8 for an 11:30 am game. Cincinnati was a 37-13 winner in their last meeting.