After facing Madison Bumgarner and Johnny Cueto to begin the series, the Pirates will face another tough Giants pitcher in 2014 All-Star Jeff Samardzija on Wednesday.
In 14 outings this season, Samardzija has posted an 8-4 record with a 3.14 ERA. The right-hander is coming off his eighth career complete game in San Francisco's 5-1 win vs. Tampa Bay, in which he allowed one run on four hits.
Samardzija has a 4-4 record and 2.25 ERA in 21 career games (10 starts) vs. the Pirates.
Francisco Liriano will start for the Pirates and try to snap his four-game losing streak. Pittsburgh broke San Francisco's eight-game winning streak with a 1-0 win Monday before losing, 15-4, on Tuesday.
Things to know about this game • The Giants have lost 10 of their last 14 regular-season games at PNC Park and have not won a series there since 2011.
• Pirates left fielder Starling Marte, who ranks second in the National League and third in the Majors with 20 stolen bases, left Tuesday's game with a foot injury.
• San Francisco is 23-14 on the road this season and has the third-best road record in the Majors.