The Reds will send ace right-hander Johnny Cueto to the mound Saturday at 1:10 p.m. ET for his second start of the season.
Cueto worked seven shutout innings in Cincinnati's 5-2 victory over Pittsburgh, his fourth consecutive Opening Day start.
Cueto was 1-2 in three starts against St. Louis last season, allowing one earned run over 15 innings in two of those starts.
The Cardinals hope right-hander Michael Wacha carries the positive momentum he got from spring training into his first start of the regular season.
Wacha dominated Grapefruit League hitters (1-0, 1.77 ERA in five starts) and hopes to put last year's shoulder issues in the rear-view mirror for good.
He was limited to 107 innings last summer due to a right shoulder stress reaction after being named MVP of the 2013 National League Championship Series. Wacha is 1-1, 2.30 in five career starts and one relief appearance against the Reds.
Three Things to Know
• Great American Ball Park is known as a hitter-friendly venue, but not so for the Cardinals when Cueto is pitching. St. Louis has hit .206 in nine games against Cueto in Cincinnati.
• Cincinnati and St. Louis will play 13 of their 19 games against each other after the All-Star break. The teams do not face each other from April 19 through July 26.
• The Cardinals have won 12 consecutive three-game series against the Reds.