Sterling Shepard had a career-high 177 yards receiving to help No. 4 Oklahoma defeat Tulsa 52-7 on Saturday.
Trevor Knight passed for 299 yards and two touchdowns and ran for another score. Alex Rossran for 90 yards and a touchdown, Keith Ford ran for 87 yards and two scores and Blake Bell, a converted quarterback who now plays tight end, caught his first career touchdown pass for the Sooners (2-0).
It was Oklahoma's sixth straight win overall and eighth in a row in the series against Tulsa. It came with a cost -- star cornerback Zack Sanchez left the game in the second quarter after injuring his right shoulder and did not return.
Tulsa quarterback Dane Evans passed for 204 yards and Keevan Lucas caught 10 passes for 84 yards for the Golden Hurricane (1-1).
Oklahoma scored 57 seconds into the game on a 7-yard touchdown run by Ford. Two possessions later, Knight broke a quarterback draw up the middle for a 31-yard touchdown.
On the next possession, Knight found Bell over the middle for a 3-yard touchdown. A 38-yard field goal by Michael Hunnicutt boosted Oklahoma's lead to 24-0.
On a third-and-goal at the Oklahoma 10, Evans fumbled in the backfield and 334-pound defensive tackle Jordan Phillips rumbled all the way back for a touchdown. The score was called back because of a personal foul, but Oklahoma retained possession. On the first play after the recovery, Ross ran 82 yards for a touchdown to make it 31-0 with 6:13 left in the second quarter.
Oklahoma rolled up 396 yards in the first half and held Tulsa to 95. The Golden Hurricane gained just seven first downs in the first half and finished with 9 yards rushing on 14 carries.
Tulsa finally scored on a 4-yard pass from Evans to Lucas, but Oklahoma quickly responded when Ford broke a 23-yard touchdown run to push Oklahoma's lead to 38-7.
Linebacker Geneo Grissom intercepted Evans and ran it back 38 yards for a score to make it 45-7, and Shepard finished a 99-yard drive with a 15-yard touchdown catch to make it 52-7.