Blake Decker threw for 252 yards and a touchdown in his debut for the Rebels, who lost to Arizona by the same score last season in Las Vegas.
Anu Solomon spent his freshman season learning Arizona's system while redshirting behind B.J. Denker, then emerged from a four-way battle to start this season's opener.
Coach Rich Rodriguez said Solomon wouldn't have to worry about looking over his shoulder if he makes a mistake, but added the other quarterbacks would likely play this season, if not Friday.
Solomon, who's from Las Vegas, had a bit of trouble with his touch early, overthrowing a couple of long passes, including one to Samajie Grant that would have been a touchdown.
He finally dialed one late in the first quarter, dropping in a pass behind coverage for a 39-yard touchdown to Nate Phillips.
Solomon kept the big plays rolling after that, squeezing a ball in front of coverage to Grant, who turned it into a 63-yard touchdown pass. Solomon added a 13-yard scoring pass to Davonte' Neal that put Arizona up 24-6 at halftime.
Solomon opened the second half with the 92-yard catch-and-run TD to Hill and Jones-Grigsby was rewarded for his hard work with a 2-yard touchdown run that made it 38-13.
Solomon finished 25 of 44 and completed passes to 10 different players. Hill (110) and Grant (101) each went over 100 yards receiving.
Like Solomon, Decker won a close quarterback battle, edging out junior Nick Sherry after transferring from Scottsdale Community College.
Decker was able to gouge out a few big chunks in the first half, including a 52-yard pass to Devonte Boyd and a 49-yard run. The Rebels couldn't capitalize on the good field position, settling for a pair of field goals and a 43-yarder that Jonathan Leiva missed at the horn.
Decker hit Anthony Williams on a 2-yard score early in the third quarter, but it was too late; Arizona was well on its way to another blowout.